Manipulating Incretin Secretion From The Gastrointestinal Tract To Regulate Feed Intake In Pigs

22 Pages
6 Jan 2015
Author(s): Ass Prof Brian Leury

The purpose of this project was to determine if manipulatuing the secretion of incretin hormones (a group of gastrointestinal hormones that effect glucose metabolism and satiety following a meal) impacts on nutrient partitioning by altering feed intake and improving the FCR. Stimulation of the incretin axis by the use of the sitagliptin (a compound used to manipulate the secretion of incretin hormones) successfully reduced feed take without altering the FCR suggesting that intake is reduced whilst weight gain remained stable. However, this effect waned as the study progressed indicating the dose of sitagliptin to live weight was not adequate to elicit a response. It is recommended that further research be conducted with higher doses of sitagliptin which is though will maintain the reduction in feed intake notes in the initial period of the study.